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Selected publications
Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation
2024, Nature Communications, IF 14.7
Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon
2021, Nature Communications, IF 14.919
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
2021, Journal for ImmunoTherapy of Cancer, IF 13.751
STAT1 maintains naïve CD8+ T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
2021, Science Advances, IF 14.136
CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells
2016, Nature Communications, IF 12.124
Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells
2011, Blood, IF 9.898
T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis
2010, Immunity, IF 24.221
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2
2007, Journal of Experimental Medicine (JEM),
IF 16.121
Publications
Lee GW, Lee SW, Kim J, Ju YJ, Kim HO, Yun CH, Cho JH. Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells. Front Immunol. 2021 Jan 28;11:616898. doi: 10.3389/fimmu.2020.616898. PMID: 33584707; PMCID: PMC7876067.
Ha DH, Chae S, Lee JY, Kim JY, Yoon J, Sen T, Lee SW, Kim HJ, Cho JH, Cho DW. Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent. Biomaterials. 2021 Jan;266:120477. doi: 10.1016/j.biomaterials.2020.120477. Epub 2020 Oct 19. PMID: 33120198.
Lee JY, Kim J, Yi J, Kim D, Kim HO, Han D, Sprent J, Lee YJ, Surh CD, Cho JH. Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells. Front Immunol. 2018 Mar 16;9:437. doi: 10.3389/fimmu.2018.00437. PMID: 29616017; PMCID: PMC5864862.
Cho JH, Sprent J. TCR tuning of T cell subsets. Immunol Rev. 2018 May;283(1):129-137. doi: 10.1111/imr.12646. PMID: 29664578.
Kim J, Lee JY, Cho K, Hong SW, Kim KS, Sprent J, Im SH, Surh CD, Cho JH. Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells. Front Immunol. 2018 Aug 23;9:1907. doi: 10.3389/fimmu.2018.01907. PMID: 30190718; PMCID: PMC6116856.
Kim HO, Cho JH. T Cell's Sense of Self: a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells. Immune Netw. 2017 Aug;17(4):201-213. doi: 10.4110/in.2017.17.4.201. Epub 2017 Aug 23. PMID: 28860950; PMCID: PMC5577298.
Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J. CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat Commun. 2016 Nov 14;7:13373. doi: 10.1038/ncomms13373. PMID: 27841348; PMCID: PMC5114568.
Nguyen HH, Kim T, Song SY, Park S, Cho HH, Jung SH, Ahn JS, Kim HJ, Lee JJ, Kim HO, Cho JH, Yang DH. Naïve CD8(+) T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-β immunosuppression in the tumor microenvironment. Sci Rep. 2016 Jun 16;6:28208. doi: 10.1038/srep28208. PMID: 27306834; PMCID: PMC4910083.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J. Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells. Blood. 2011 Jul 7;118(1):116-28. doi: 10.1182/blood-2010-11-317396. Epub 2011 May 3. PMID: 21540458.
Cho JH, Kim HO, Surh CD, Sprent J. T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity. 2010 Feb 26;32(2):214-26. doi: 10.1016/j.immuni.2009.11.014. Epub 2010 Feb 4. PMID: 20137986; PMCID: PMC2830358.
Sprent J, Cho JH, Boyman O, Surh CD. T cell homeostasis. Immunol Cell Biol. 2008 May-Jun;86(4):312-9. doi: 10.1038/icb.2008.12. Epub 2008 Mar 25. PMID: 18362947.
Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med. 2007 Aug 6;204(8):1787-801. doi: 10.1084/jem.20070740. Epub 2007 Jul 30. PMID: 17664294; PMCID: PMC2118670.
Sprent J, Cho JH. Self/non-self discrimination and the problem of keeping T cells alive. Immunol Cell Biol. 2008 Jan;86(1):54-6. doi: 10.1038/sj.icb.7100139. Epub 2007 Dec 11. PMID: 18071359.
Patents
Lee GW, Lee SW, Kim J, Ju YJ, Kim HO, Yun CH, Cho JH. Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells. Front Immunol. 2021 Jan 28;11:616898. doi: 10.3389/fimmu.2020.616898. PMID: 33584707; PMCID: PMC7876067.
Ha DH, Chae S, Lee JY, Kim JY, Yoon J, Sen T, Lee SW, Kim HJ, Cho JH, Cho DW. Therapeutic effect of decellularized extracellular matrix-based hydrogel for radiation esophagitis by 3D printed esophageal stent. Biomaterials. 2021 Jan;266:120477. doi: 10.1016/j.biomaterials.2020.120477. Epub 2020 Oct 19. PMID: 33120198.
Lee JY, Kim J, Yi J, Kim D, Kim HO, Han D, Sprent J, Lee YJ, Surh CD, Cho JH. Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells. Front Immunol. 2018 Mar 16;9:437. doi: 10.3389/fimmu.2018.00437. PMID: 29616017; PMCID: PMC5864862.
Cho JH, Sprent J. TCR tuning of T cell subsets. Immunol Rev. 2018 May;283(1):129-137. doi: 10.1111/imr.12646. PMID: 29664578.
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